Analytical Data
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基因名
DDX41
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简介
DDX41 protein, a probable ATP-dependent RNA helicase, plays a crucial role in post-transcriptional gene expression, suggesting involvement in pre-mRNA splicing. As an ATP-dependent RNA helicase, DDX41 likely contributes to dynamic RNA unwinding, facilitating various aspects of RNA metabolism. Its multifunctional role underscores its significance in the intricate machinery governing gene expression and RNA processing within the cell. DDX41 Protein, Human (FLAG) is the recombinant human-derived DDX41 protein, expressed by E. coli , with C-Flag labeled tag.
- Application
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别名
DDX41; Probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog
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种属
Human
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表达系统
E. coli
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标签
C-Flag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UJV9
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表达区间
M1-F622
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDX41 is a member of the DEAD-box RNA helicase family, playing a crucial role in various cellular processes, including RNA metabolism and regulation of gene expression. Recent studies have highlighted its significant involvement in the innate immune response, particularly in recognizing cytoplasmic DNA and activating immune signaling pathways. Mutations in the DDX41 gene have been linked to certain hematological malignancies, notably myeloid neoplasms, underscoring its importance in both cancer biology and immunology. The recombinant expression of DDX41 protein allows for detailed functional studies, enabling researchers to dissect its molecular mechanisms and interactions in the context of immune response and tumorigenesis. Understanding DDX41's role in these pathways not only provides insights into fundamental biology but also holds potential for developing targeted therapeutics for diseases associated with its dysregulation. As DDX41 continues to emerge as a significant player in both cancer and immune system function, comprehensive studies on its recombinant protein will further illuminate its mechanisms of action and therapeutic implications in hematological disorders and beyond.
