Analytical Data
-
基因名
GNPDA2
-
简介
The GNPDA2 protein catalyzes the reversible conversion of α-D-glucosamine 6-phosphate to β-D-fructose 6-phosphate and ammonium ions, which is a key step in de novo UDP-GlcNAc biosynthesis. GNPDA2 Protein, Human (His) is the recombinant human-derived GNPDA2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
-
别名
GNPDA2; Glucosamine-6-phosphate isomerase 2; Glucosamine-6-phosphate deaminase 2; GNPDA 2; GlcN6P deaminase 2; Glucosamine-6-phosphate isomerase SB52
-
种属
Human
-
表达系统
E. coli
-
标签
N-6*His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8TDQ7
-
表达区间
R2-N276
-
蛋白长度
Partial
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GNPDA2, or glucosamine-6-phosphate deaminase 2, is a critical enzyme that participates in the hexosamine biosynthetic pathway, which is essential for glycosylation processes in cells. Recent studies have highlighted the role of GNPDA2 in various biological functions, including its involvement in cellular metabolism and the regulation of insulin signaling. Given its association with metabolic disorders, such as obesity and diabetes, researchers have been particularly interested in understanding the molecular mechanisms underlying GNPDA2 activity. The exploration of GNPDA2 as a potential therapeutic target has led to increased focus on developing recombinant forms of the protein for detailed biochemical studies. Characterizing recombinant GNPDA2 allows scientists to investigate its kinetic properties, substrate specificity, and regulatory mechanisms, thus providing insights into its biological functions and potential roles in disease. Furthermore, the study of GNPDA2's structure-function relationship is essential for drug design, as small-molecule inhibitors could be developed to modulate its activity. Overall, the study of GNPDA2 and its recombinant protein offers valuable opportunities for advancing our understanding of metabolic pathways and their implications in health and disease.
