Analytical Data
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Gene name
GNPDA2
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简介
The GNPDA2 protein catalyzes the reversible conversion of α-D-glucosamine 6-phosphate to β-D-fructose 6-phosphate and ammonium ions, which is a key step in de novo UDP-GlcNAc biosynthesis. GNPDA2 Protein, Human is the recombinant human-derived GNPDA2 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
GNPDA2; Glucosamine-6-phosphate isomerase 2; Glucosamine-6-phosphate deaminase 2; GNPDA 2; GlcN6P deaminase 2; Glucosamine-6-phosphate isomerase SB52
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TDQ7
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Expression Region
R2-N276
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GNPDA2, or glucosamine-6-phosphate deaminase 2, is a critical enzyme that participates in the hexosamine biosynthetic pathway, which is essential for glycosylation processes in cells. Recent studies have highlighted the role of GNPDA2 in various biological functions, including its involvement in cellular metabolism and the regulation of insulin signaling. Given its association with metabolic disorders, such as obesity and diabetes, researchers have been particularly interested in understanding the molecular mechanisms underlying GNPDA2 activity. The exploration of GNPDA2 as a potential therapeutic target has led to increased focus on developing recombinant forms of the protein for detailed biochemical studies. Characterizing recombinant GNPDA2 allows scientists to investigate its kinetic properties, substrate specificity, and regulatory mechanisms, thus providing insights into its biological functions and potential roles in disease. Furthermore, the study of GNPDA2's structure-function relationship is essential for drug design, as small-molecule inhibitors could be developed to modulate its activity. Overall, the study of GNPDA2 and its recombinant protein offers valuable opportunities for advancing our understanding of metabolic pathways and their implications in health and disease.
