Analytical Data
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基因名
Neurturin
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简介
Neurturin protein, vital in neurobiology, is key to supporting sympathetic neuron survival and implicated in regulating the central nervous system (CNS). It influences neural growth, stability, and may modulate non-neuronal cell populations. Neurturin, a homodimer linked by disulfide bonds, maintains structural integrity for diverse cellular functions beyond neuronal survival. Neurturin Protein, Human is the recombinant human-derived Neurturin protein, expressed by E. coli , with tag free.
- Application
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生物活性
Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 31.8 ng/mL in the presence of 100 ng/mL Human GFR alpha-2, corresponding to a specific activity is 3.145×104 units/mg. Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 31.8 ng/mL in the presence of 100ng/mL Human GFR alpha-2, corresponding to a specific activity is 3.145×104 units/mg.
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别名
Neurturin; NRTN
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
Q99748
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表达区间
A96-V197
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蛋白长度
Full Length of Mature Protein
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurturin is a member of the glial cell line-derived neurotrophic factor (GDNF) family, which plays a crucial role in the survival and maintenance of various neuronal populations, particularly those in the peripheral nervous system. Research into Neurturin emerged from the need to understand its neuroprotective properties and potential therapeutic applications for neurodegenerative diseases. Unlike other neurotrophic factors, Neurturin exhibits selective actions that promote the survival of specific neuronal subtypes, making it a candidate for targeted therapies in conditions like Parkinson's disease and amyotrophic lateral sclerosis (ALS). The study of Neurturin has focused on its mechanism of action, receptor binding, and downstream signaling pathways, revealing its ability to activate the Ret receptor tyrosine kinase and modulate pathways involved in neuronal survival and differentiation. Moreover, preclinical studies have shown promising results in animal models, where Neurturin administration helped restore motor functions and neuronal integrity. As research progresses, understanding Neurturin’s role in neural development and its potential to repair or regenerate damaged neurons continues to be a significant area of interest, paving the way for innovative treatment strategies in neurodegenerative conditions.
