Analytical Data
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Gene name
MST2
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简介
MST2 protein is a stress-activated kinase that plays an important role in the Hippo signaling pathway, regulates organ size and inhibits tumors. Cleaved MST2 enters the nucleus and induces apoptosis through chromatin condensation. MST2 Protein, Human (sf9, GST) is the recombinant human-derived MST2 protein, expressed by sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
STK3; Serine/threonine-protein kinase 3; Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13188
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Expression Region
M1-F491
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AA Sequence
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
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Protein Length
Full Length
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Molecular Weight
82.8 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MST2, or Mammalian Sterile 20-like kinase 2, is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, apoptosis, and stress responses. It is part of the Hippo signaling pathway, which is essential for regulating organ size and maintaining tissue homeostasis. Dysregulation of MST2 has been implicated in various diseases, including cancer, where its activity can influence tumor suppression and metastasis. Research has increasingly focused on the mechanism by which MST2 exerts its functions, its interaction with downstream effectors, and its potential as a therapeutic target. The recombinant expression of MST2 has allowed for detailed biochemical characterization, and the development of MST2 inhibitors has gained interest in the context of cancer therapy. Understanding MST2's structure, function, and regulatory mechanisms can provide insights into its role in disease and inform strategies for developing novel therapeutic interventions. As researchers continue to explore MST2, it holds promise not only for fundamental cell biology but also for translational research aimed at treating diseases associated with the dysregulation of this kinase.
