Analytical Data
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Gene name
Claudin-6
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简介
Claudin-6/CLDN6 Protein-VLP is pivotal in targeted elimination of intercellular spaces within tight junctions, ensuring cell barrier integrity and polarity. Moreover, it serves as a receptor for hepatitis C virus (HCV), facilitating viral entry into hepatic cells. Claudin-6 Protein-Nanodisc, Human (HEK293, GFP, His) is the recombinant human-derived Claudin-6 protein, expressed by HEK293, with C-His and C-GFP labeled tag.
- Application
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Alternative Names
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
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Species
Human
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Source
HEK293
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Tag
C-His;C-GFP
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56747-1
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Expression Region
M1-V220
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Protein Length
Full Length of Isoform-1
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Molecular Weight
37.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Claudin-6 is a member of the claudin family of proteins, which are critical components of tight junctions in epithelial cells. These proteins play a crucial role in maintaining cellular integrity by regulating paracellular permeability and enabling selective barrier functions within tissues. Recent studies have highlighted Claudin-6's involvement in various physiological processes and its potential implications in disease, particularly in cancer. Notably, Claudin-6 is overexpressed in certain malignancies, including ovarian and gastric cancers, making it a focal point for targeted therapies and immunotherapeutic strategies. The recombinant production of Claudin-6 provides a valuable tool for investigating its role in tumor biology and for developing diagnostic and therapeutic applications. Understanding the structural and functional characteristics of Claudin-6 can aid in elucidating its mechanisms of action and reveal novel insights for clinical use. Research on Claudin-6 also highlights the broader significance of tight junction proteins in maintaining cellular homeostasis and their potential utility in regenerative medicine and tissue engineering. Overall, Claudin-6 remains an intriguing subject for further exploration due to its dual utility in understanding basic cellular processes and advancing therapeutic interventions in cancer treatment.











