Analytical Data
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基因名
Claudin-6
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简介
Claudin-6/CLDN6 Protein-VLP is pivotal in targeted elimination of intercellular spaces within tight junctions, ensuring cell barrier integrity and polarity. Moreover, it serves as a receptor for hepatitis C virus (HCV), facilitating viral entry into hepatic cells. Claudin-6 Protein-Nanodisc, Human (HEK293, GFP, His) is the recombinant human-derived Claudin-6 protein, expressed by HEK293, with C-His and C-GFP labeled tag.
- Application
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别名
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
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种属
Human
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表达系统
HEK293
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标签
C-His;C-GFP
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56747-1
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表达区间
M1-V220
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蛋白长度
Full Length of Isoform-1
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分子量
37.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Claudin-6 is a member of the claudin family of proteins, which are critical components of tight junctions in epithelial cells. These proteins play a crucial role in maintaining cellular integrity by regulating paracellular permeability and enabling selective barrier functions within tissues. Recent studies have highlighted Claudin-6's involvement in various physiological processes and its potential implications in disease, particularly in cancer. Notably, Claudin-6 is overexpressed in certain malignancies, including ovarian and gastric cancers, making it a focal point for targeted therapies and immunotherapeutic strategies. The recombinant production of Claudin-6 provides a valuable tool for investigating its role in tumor biology and for developing diagnostic and therapeutic applications. Understanding the structural and functional characteristics of Claudin-6 can aid in elucidating its mechanisms of action and reveal novel insights for clinical use. Research on Claudin-6 also highlights the broader significance of tight junction proteins in maintaining cellular homeostasis and their potential utility in regenerative medicine and tissue engineering. Overall, Claudin-6 remains an intriguing subject for further exploration due to its dual utility in understanding basic cellular processes and advancing therapeutic interventions in cancer treatment.
