Analytical Data
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Gene name
CD96
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简介
CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (Biotinylated, HEK293, hFc, Avi) is the recombinant human-derived CD96 protein, expressed by HEK293, with Avi and C-hFc labeled tag.
- Application
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Alternative Names
T-cell surface protein tactile, Cell surface antigen CD96, T cell-activated increased late expression protein
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Species
Human
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Source
HEK293
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Tag
Avi;C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40200-2
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Expression Region
M1-M503
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Protein Length
Partial
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Molecular Weight
110.43 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD96, also known as Tactile or DNAM-1, is a type I transmembrane protein that plays a critical role in immune responses, particularly in mediating interactions between immune cells and tumor cells. It belongs to the immunoglobulin superfamily and is primarily expressed on natural killer (NK) cells, CD8+ T cells, and activated T cells. Understanding the function of CD96 is crucial due to its involvement in regulating immune cell activation, adhesion, and cytotoxicity. Recent studies have highlighted its dual role in promoting or inhibiting immune responses, depending on the context, which raises questions about its potential as a therapeutic target in cancer and autoimmune diseases. The generation of recombinant CD96 protein allows for detailed exploration of its biological functions and interactions. These investigations aim to elucidate the complex signaling pathways mediated by CD96, facilitate the development of immunotherapies, and enhance our understanding of immune evasion mechanisms utilized by tumors. Additionally, recombinant CD96 can be employed in various experimental settings, including binding assays, functional assays, and structural studies, providing valuable insights into its role in cellular communication and immune modulation. Overall, research on recombinant CD96 protein is pivotal for advancing our knowledge of immune system regulation and developing innovative strategies to harness immune responses against malignancies.
