Analytical Data
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Gene name
C1qR1/CD93
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简介
The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) . Its interaction with these immune factors suggests a role in coordinating the innate immune response. C1qR1/CD93 Protein, Human (HEK293, hFc) is the recombinant human-derived C1qR1/CD93 protein, expressed by HEK293, with C-hFc labeled tag.
- Application
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Alternative Names
rHuCD93, His; Complement Component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPY3
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Expression Region
T22-L580
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Protein Length
Partial
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Molecular Weight
125 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C1qR1, also known as CD93, is a receptor that plays a crucial role in the immune system, particularly in the regulation of inflammation and the clearance of apoptotic cells. It is predominantly expressed on the surface of various immune cells, including monocytes and dendritic cells, and is involved in mediating signaling pathways that promote phagocytosis and innate immune responses. The study of recombinant C1qR1/CD93 proteins has garnered increasing attention due to their potential therapeutic applications in diseases characterized by chronic inflammation and impaired immune responses, such as autoimmune disorders and cancer. Understanding the molecular mechanisms by which C1qR1 interacts with its ligands and regulates immune functions can provide insights into novel strategies for enhancing immune responses or modulating inflammation. Furthermore, the production of recombinant C1qR1 proteins allows researchers to investigate its structure-function relationship, assess its role in various cellular pathways, and evaluate its potential as a biomarker for disease. Overall, the research into C1qR1/CD93 recombinant proteins holds promise for the development of innovative immunotherapeutic approaches aimed at restoring immune balance and improving patient outcomes in a range of diseases.
