Analytical Data
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Gene name
TRAT1
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简介
TRAT1 protein stabilizes the T-cell antigen receptor (TCR)/CD3 complex on T-cell surfaces. As a homodimer linked by disulfide bonds, TRAT1 interacts with CD3Z, enhancing the structural integrity and function of the TCR/CD3 complex. Phosphorylated TRAT1 also engages with PIK3R1, indicating its role in signaling pathways related to T-cell activation and response. TRAT1 Protein, Human (His) is the recombinant human-derived TRAT1 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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Alternative Names
T-Cell Receptor-Associated Transmembrane Adapter 1; T-Cell Receptor-Interacting Molecule; TRIM; pp29/30; TRAT1; TCRIM; HSPC062
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q6PIZ9
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Expression Region
N29-N186
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Protein Length
Cytoplasmic Domain
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Molecular Weight
30.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRAT1 (T cell receptor associated transmembrane adaptor protein 1) is a critical component in the regulation of T cell signaling and immune responses. This protein plays a pivotal role in the assembly of the T cell receptor (TCR) complex, facilitating the transmission of signals upon antigen recognition. TRAT1 is known to interact with various signaling molecules, influencing T cell activation, proliferation, and differentiation. Recent studies have suggested that TRAT1 may be involved in the modulation of immune tolerance and autoimmunity, highlighting its potential as a therapeutic target for immunological disorders. Given its central role in T cell function, researchers have focused on producing TRAT1 recombinant proteins to better understand its structure, function, and the mechanisms through which it influences T cell signaling pathways. The characterization of TRAT1 in a recombinant form will enable detailed investigations into its interactions with other cellular components, paving the way for novel immunotherapeutic strategies. Furthermore, exploring the functional implications of TRAT1 in various disease contexts, including cancer and autoimmune diseases, could provide insights into its role in disease progression and potential avenues for intervention. Overall, the study of TRAT1 recombinant proteins holds significant promise for advancing our understanding of T cell biology and developing targeted therapies to modulate immune responses effectively.
