Analytical Data
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Gene name
CD4
- Application
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Alternative Names
CD4 molecule
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Species
Others
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
ABS50090.1
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Expression Region
M1-L401
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Protein Length
Partial
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Molecular Weight
52 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD4 is a glycoprotein found on the surface of immune cells, particularly T-helper cells, playing a crucial role in the immune response by acting as a co-receptor for the T-cell receptor (TCR). It facilitates the recognition of antigens presented by major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. The study of CD4 recombinant proteins has gained significance largely due to their potential applications in vaccine development, diagnostics, and therapeutic interventions for diseases, including HIV, where CD4 serves as a primary entry point for the virus into host cells. Recombinant CD4 proteins can be engineered to enhance immune responses, stabilize interactions with MHC molecules, or even serve as decoys to block viral infections. Furthermore, understanding the structure-function relationships of CD4 and its associated signaling pathways is vital for designing effective immunotherapies and for elucidating the mechanisms underlying immune dysregulation in various diseases. Recent advancements in genetic engineering and protein expression systems have enabled the production of highly purified CD4 proteins, paving the way for innovative approaches in research and clinical applications, including the potential modulation of immune responses in autoimmune diseases and cancer therapy. This growing body of research emphasizes the importance of CD4 as not only a key player in immune function but also a versatile tool in the development of novel therapeutic strategies.











