Analytical Data
-
Gene name
GSK3α
- Application
-
Alternative Names
Serine/threonine-protein kinase GSK3A
-
Species
Rat
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 95% as determined by SDS-PAGE.
-
Uniprot
P18265
-
Expression Region
Ile122~Asn416
-
Molecular Weight
38kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GSK3α (Glycogen Synthase Kinase 3 Alpha) is a serine/threonine kinase that plays a critical role in various cellular processes, including metabolism, cell proliferation, differentiation, and apoptosis. It is particularly well-known for its involvement in the Wnt signaling pathway, which is essential for embryonic development and cancer progression. Dysregulation of GSK3α has been associated with numerous diseases, including neurodegenerative disorders such as Alzheimer's disease and various types of cancer. Research into GSK3α recombinant protein has gained significant attention due to its potential as a therapeutic target. Understanding the structure and function of GSK3α can aid in the development of specific inhibitors that could modulate its activity in disease states. Additionally, studying GSK3α's interactions with other proteins and pathways provides insights into its multifaceted roles in cellular signaling. The production of recombinant GSK3α allows scientists to explore its enzymatic properties and regulatory mechanisms in a controlled environment. This research is crucial for elucidating the protein's function and its implications in health and disease, paving the way for innovative strategies in drug development targeting GSK3α-related disorders.
