Analytical Data
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Gene name
Lonp1
- Application
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Alternative Names
Prss15
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8CGK3
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Expression Region
G65-R949
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Lonp1, a member of the Lon protease family, plays a crucial role in mitochondrial protein quality control and cellular homeostasis. It is involved in the degradation of misfolded or damaged proteins, thereby maintaining mitochondrial function and preventing oxidative stress. Research on Lonp1 has gained significant attention due to its implications in various diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Dysregulation of Lonp1 activity has been linked to the accumulation of dysfunctional mitochondria, contributing to the pathogenesis of these conditions. Scientists are exploring the mechanistic pathways of Lonp1, including its substrate specificity and interaction with mitochondrial dynamics, to understand its contribution to health and disease. Additionally, understanding the functional roles of Lonp1 could pave the way for novel therapeutic strategies aimed at enhancing mitochondrial quality control, potentially mitigating the effects of age-related diseases and improving cell viability under stress conditions. Ongoing studies are focusing on the structural biology of Lonp1 to design inhibitors or activators that could modulate its activity, thus offering insights into the potential of targeting Lonp1 for therapeutic intervention. The growing body of evidence highlights the importance of Lonp1 not only as a critical player in mitochondrial maintenance but also as a potential biomarker for disease progression and a target for innovative treatment options.
