Analytical Data
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基因名
OTUD3
- Application
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别名
KIAA0459
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T2D3
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表达区间
E52-D209
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OTUD3 is a deubiquitinating enzyme that belongs to the ovarian tumor domain (OTU) family and has gained attention in recent years due to its critical roles in cellular processes such as protein degradation, signal transduction, and stress responses. Ubiquitination is a post-translational modification that regulates protein stability and function, and the removal of ubiquitin chains by deubiquitinating enzymes (DUBs) is essential for maintaining cellular homeostasis. OTUD3 specifically targets ubiquitinated proteins and plays a significant role in modulating various signaling pathways, including those involved in immune response and cell cycle regulation. Research has shown that OTUD3 can influence the stability and activity of key proteins such as p53 and NF-kB, thereby impacting tumorigenesis and cellular stress responses. Additionally, OTUD3 has been implicated in several diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target. Understanding the molecular mechanisms by which OTUD3 acts is essential for developing new strategies for disease intervention. Therefore, the study of OTUD3 recombinant protein not only provides insights into its functional role and structural characteristics but also highlights its potential in translational applications. As the field of proteomics and targeted therapies advances, OTUD3 stands out as a promising candidate for future research aimed at harnessing its DUB activity for therapeutic benefits.
