Analytical Data
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基因名
IGFBP-3
- Application
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别名
Insulin-like growth factor-binding protein 3; IGF-BP3; IBP-3; IGFBP-3
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种属
Cynomolgus
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_005549698.1
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表达区间
G28-L291
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蛋白长度
Partial
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分子量
41-44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Insulin-like growth factor binding protein 3 (IGFBP-3) is a key regulator of insulin-like growth factor (IGF) actions, playing a critical role in cellular growth, differentiation, and apoptosis. It binds to IGF with high affinity, modulating its bioavailability and activity in various physiological contexts. Given its significant involvement in cancer biology, particularly in tumor growth and metastasis, IGFBP-3 has garnered attention as a potential therapeutic target. Research has shown that alterations in IGFBP-3 levels are associated with various malignancies, emphasizing its importance in cancer prognosis and treatment. Moreover, recombinant forms of IGFBP-3 are being explored for therapeutic applications due to their ability to inhibit tumor cell proliferation and induce apoptosis in cancerous cells. The production of recombinant IGFBP-3 allows for high-purity preparations for in vitro and in vivo studies, facilitating insights into its biological functions and mechanisms of action. As researchers continue to delineate the pathways affected by IGFBP-3, its potential as a biotherapeutic agent is becoming increasingly apparent, opening avenues for innovative cancer treatments. Understanding the biology of IGFBP-3 not only enhances our grasp of IGF signaling but also presents opportunities for novel interventions in diseases linked to IGF dysregulation, thereby underlining the importance of ongoing research in this critical field.












