Analytical Data
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基因名
Can f 4
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简介
Can f 4 Protein, Canine (HEK293, His), an IgE-binding dog dander protein, is an important respiratory allergen. Can f 4 Protein is a dog allergen of the lipocalin family[1]. Can f 4 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 4 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Allergen Can f 4
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种属
Canine
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
NP_001177855.1
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表达区间
Q17-E174
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蛋白长度
Full Length of Mature Protein
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分子量
19 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Can f 4 is a major allergen derived from domestic dogs, specifically identified as a protein expressed in their saliva, skin, and urine. As a significant contributor to pet allergy, Can f 4 has garnered considerable attention within the fields of immunology and allergology. The increase in pet ownership globally has led to a rise in allergic reactions among individuals sensitive to dog allergens, highlighting the need for effective diagnostic and therapeutic strategies. Studies on Can f 4's structure and function provide insight into its role in the allergenic response. Understanding the molecular basis of its allergenicity can facilitate the development of targeted immunotherapies and improve methods for allergen detection. Additionally, the recombinant production of Can f 4 allows for large-scale availability of the protein, which can be utilized in research and clinical settings. By exploring the IgE-binding properties of Can f 4, researchers aim to uncover potential cross-reactivity with other allergens, ultimately contributing to a deeper understanding of allergic mechanisms. This research not only aids in improving allergy management but also enhances the quality of life for individuals affected by pet allergies.
