Analytical Data
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基因名
GALNT10
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简介
GALNT10 protein assumes a crucial role in the initiation of O-linked oligosaccharide biosynthesis, facilitating the transfer of an N-acetyl-D-galactosamine residue to specific serine or threonine residues on protein receptors. With its catalytic activity, GALNT10 demonstrates specificity towards substrates such as Muc5Ac and EA2 peptides, contributing to the intricate process of protein glycosylation and subsequent cellular functions. GALNT10 Protein, Human (HEK293, His) is the recombinant human-derived GALNT10 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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别名
Polypeptide N-acetylgalactosaminyltransferase 10; GalNAc-T10
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种属
Human
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表达系统
HEK293
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标签
N-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q86SR1-1
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表达区间
T39-N603
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氨基酸序列
TPGGSGAAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKRVAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWREDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDCSESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN
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蛋白长度
Partial
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分子量
70-75 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GALNT10, a member of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family, plays a crucial role in the O-glycosylation of proteins, a post-translational modification that influences various biological processes, including cell adhesion, signaling, and immune responses. Research has revealed that GALNT10 is involved in the glycosylation of mucins and other glycoproteins, which are essential for maintaining epithelial integrity and function. Abnormal expression or activity of GALNT enzymes, including GALNT10, has been linked to various diseases, particularly cancer, where altered glycosylation patterns can contribute to tumor progression and metastasis. Understanding the functional mechanisms of GALNT10 is vital for elucidating its role in both normal physiological processes and disease states. By studying the recombinant GALNT10 protein, researchers aim to dissect its enzymatic activity, substrate specificity, and regulatory mechanisms. Additionally, investigating GALNT10 may provide insights into potential therapeutic targets for modulating glycosylation processes in diseases characterized by aberrant glycosylation patterns. Overall, the study of GALNT10 is essential for advancing our knowledge of glycosylation biology and its implications in health and disease.
