Analytical Data
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基因名
Integrin alpha 8 beta 1
- Application
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别名
ITG-A8
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P53708
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表达区间
Asp907~Ala1063
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分子量
52kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha 8 beta 1 is a crucial cell surface receptor that belongs to the integrin family of proteins, playing a significant role in cell adhesion, migration, and signaling. This particular integrin is primarily expressed in various tissues, including the brain and kidney, and is involved in several physiological processes, including tissue development and repair, as well as immune responses. Its interactions with the extracellular matrix (ECM) are vital for maintaining tissue architecture and function. Recent studies have highlighted the potential of integrin alpha 8 beta 1 in cancer biology, particularly in tumor progression and metastasis, suggesting that it may serve as a promising biomarker and therapeutic target. Given its diverse roles, the recombinant expression of integrin alpha 8 beta 1 protein has become a focus of research to elucidate its structure-function relationships, which can provide insights into its mechanisms of action in health and disease. This research may pave the way for the development of integrin-based therapies and enhance our understanding of its involvement in various pathologies, including fibrotic diseases and cancers. Overall, the recombinant protein serves as a valuable tool in both basic and applied biomedical research, facilitating the exploration of integrin-mediated cellular processes and the potential therapeutic interventions targeting this integrin's signaling pathways.
