Analytical Data
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Gene name
ACK1
- Application
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Alternative Names
ACK; ACK1; Activated CDC42 Associated Kinase 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q07912
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Expression Region
Leu126~Leu385
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACK1 (Activated CDC42-associated kinase 1) is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including growth, survival, and migration. Its dysregulation has been implicated in several diseases, particularly cancer, where it promotes tumorigenesis and metastasis. Given the vital functions of ACK1 in signaling pathways, understanding its structure and function is essential for developing targeted therapies. Recent studies have revealed its involvement in processes such as epithelial-mesenchymal transition and angiogenesis, highlighting its potential as a therapeutic target. The recombinant expression of ACK1 protein has garnered significant attention as it allows researchers to investigate its enzymatic activity, phosphorylation sites, and interaction with other cellular partners. Furthermore, the development of ACK1 inhibitors can lead to novel cancer treatments, making the study of this protein particularly relevant in the field of oncology.
