Analytical Data
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Gene name
Kallikrein-15
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简介
Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
ACO protease; KLK15; kallikrein-related peptidase 15
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2R5
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Expression Region
Q17-N256
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Protein Length
Full Length of Mature Protein
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Molecular Weight
53.1 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Kallikrein-15 (KLK15) is a member of the kallikrein family of serine proteases, known for their role in various physiological processes including tissue remodeling, inflammation, and hormone regulation. Research into KLK15 has gained significant traction due to its potential implications in cancer biology, particularly breast cancer and other malignancies. This serine protease is thought to be involved in the regulation of the extracellular matrix and may influence tumor progression and metastasis. Additionally, KLK15 has been identified as a biomarker for certain pathological conditions, providing insights into its possible role in disease diagnosis and prognosis. The recombinant production of KLK15 allows for detailed studies into its enzymatic properties, substrate specificity, and functional roles within biological systems. Understanding the mechanisms by which KLK15 operates can lead to novel therapeutic strategies and biomarker development. Furthermore, the exploration of KLK15 may shed light on the broader functions of the kallikrein family in health and disease, highlighting its significance in biomedical research.
