Analytical Data
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基因名
DPEP2
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简介
The DPEP2 protein functions as a dipeptidase capable of hydrolyzing leukotriene D4 (LTD4) into leukotriene E4 (LTE4) and cysteinyl diglycine. In addition to its dipeptidase activity, DPEP2 serves as a modulator of macrophage inflammatory responses by acting as a modulator of the NF-kappaB inflammatory signaling pathway. DPEP2 Protein, Human (HEK293, Fc) is the recombinant human-derived DPEP2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Dipeptidase 2; DPEP2; Membrane-bound dipeptidase 2; MBD-2
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H4A9-1
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表达区间
A33-S376
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蛋白长度
Partial
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分子量
71.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DPEP2, or Dipeptidase 2, is a membrane-bound enzyme that plays a significant role in the metabolism of dipeptides in various biological processes. Its interest in research has increased notably due to its involvement in critical physiological functions, such as the regulation of blood pressure, immune response, and neurotransmission. Recent studies have highlighted the enzyme's potential as a therapeutic target in treating diseases related to metabolic disorders and certain cancers, where altered peptidase activity may contribute to pathophysiology. Moreover, DPEP2's role in the degradation of bioactive peptides suggests its significance in modulating signaling pathways and maintaining homeostasis. The recombinant expression of DPEP2 provides an opportunity for detailed biochemical and structural characterization, facilitating a better understanding of its function and regulation. This research is vital for exploring the enzyme's potential in drug design and development, offering insights into novel therapeutic strategies targeting DPEP2-related pathways. Consequently, the investigation of DPEP2 as a recombinant protein serves not only to elucidate its biological properties but also to assess its application in clinical settings, potentially advancing the field of molecular medicine.
