Analytical Data
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Gene name
ABAT
- Application
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Alternative Names
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22) GABA aminotransferase
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P80404
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Expression Region
29-500aa
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Molecular Weight
73.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABAT, or amino acid decarboxylase, is an important enzyme involved in the metabolism of amino acids, particularly in the synthesis of γ-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the central nervous system. Research into ABAT has gained momentum due to its potential roles in various physiological and pathological processes, including its implications in neurological disorders such as epilepsy, anxiety, and schizophrenia. The enzyme's activity can influence GABA levels, which are crucial for maintaining neuronal excitability and a balanced mood. Furthermore, alterations in ABAT expression or function have been linked to metabolic disorders and certain neurodevelopmental conditions. The recombinant expression of ABAT allows for the production of the enzyme in a controlled environment, facilitating detailed biochemical studies and the exploration of its structure-function relationships. This has paved the way for the development of novel therapeutic strategies aimed at modulating ABAT activity. By understanding how ABAT operates and its interactions within metabolic pathways, researchers hope to uncover targeted interventions that could restore normal neurotransmitter balance and improve treatment outcomes for patients suffering from related disorders. Given the critical role of GABAergic signaling in the brain, ABAT remains a significant focus in neurobiological research, highlighting the importance of comprehensive studies on its recombinant protein for both basic science and clinical applications.
