Cat: IPD-X36924

Recombinant Human ABAT Protein,His

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Analytical Data

  • 基因名

    ABAT

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    GABAT; L-AIBAT; 4-Anobutyrate Tansaminase; (S)-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P80404

  • 表达区间

    Pro249~Lys500

  • 分子量

    32kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

ABAT, or amino acid decarboxylase, is an important enzyme involved in the metabolism of amino acids, particularly in the synthesis of γ-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the central nervous system. Research into ABAT has gained momentum due to its potential roles in various physiological and pathological processes, including its implications in neurological disorders such as epilepsy, anxiety, and schizophrenia. The enzyme's activity can influence GABA levels, which are crucial for maintaining neuronal excitability and a balanced mood. Furthermore, alterations in ABAT expression or function have been linked to metabolic disorders and certain neurodevelopmental conditions. The recombinant expression of ABAT allows for the production of the enzyme in a controlled environment, facilitating detailed biochemical studies and the exploration of its structure-function relationships. This has paved the way for the development of novel therapeutic strategies aimed at modulating ABAT activity. By understanding how ABAT operates and its interactions within metabolic pathways, researchers hope to uncover targeted interventions that could restore normal neurotransmitter balance and improve treatment outcomes for patients suffering from related disorders. Given the critical role of GABAergic signaling in the brain, ABAT remains a significant focus in neurobiological research, highlighting the importance of comprehensive studies on its recombinant protein for both basic science and clinical applications.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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