Analytical Data
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基因名
ABL1
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简介
ABL1, Human (GST) is a non-receptor tyrosine-protein kinase. ABL1, Human is implicated in a wide range of cellular processes, including regulation of cell growth and survival, oxidative stress and DNA-damage responses, actin dynamics and cell migration, transmission of information about the cellular environment through integrin signaling.
- Application
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别名
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine protein kinase 1; Abl 1; ABL; JTK7; p150; Proto oncogene tyrosine protein kinase ABL1
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种属
Human
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表达系统
E. coli
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00519-1
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表达区间
I4-T194
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氨基酸序列
ICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNT
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蛋白长度
Partial
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分子量
48.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABL1, or Abelson murine leukemia virus gene 1, is a crucial proto-oncogene that encodes a non-receptor tyrosine kinase, playing a significant role in various cellular processes, including cell division, differentiation, and apoptosis. Its dysregulation is prominently associated with several types of cancers, particularly chronic myeloid leukemia (CML), where the BCR-ABL fusion protein acts as a constitutively active tyrosine kinase, driving malignant transformation. The development of BCR-ABL-targeted therapies, notably Imatinib (Gleevec), revolutionized CML treatment and highlighted the importance of ABL1 in cancer biology. Researchers have been focused on producing recombinant ABL1 proteins to better understand its biochemical properties, signaling pathways, and interactions with other molecules. This research aids in deciphering the mechanisms of BCR-ABL-associated oncogenesis and helps in identifying potential therapeutic targets. Additionally, the generation of ABL1 protein variants and their recombinant forms offers insights into drug resistance mechanisms and the development of second-generation tyrosine kinase inhibitors. As studies continue to explore the nuances of ABL1’s role in cancer, the insights gained from recombinant ABL1 protein research are crucial for advancing personalized medicine strategies and improving therapeutic outcomes for patients with ABL1-related malignancies.
