Analytical Data
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基因名
KYAT1
- Application
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别名
KATI; GTK; Cysteine-S-conjugate beta-lyase; Glutamine-phenylpyruvate transaminase; Kyneurenine Aminotransferase; Kynurenine Oxoglutarate Transaminase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q16773
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表达区间
Met1~Leu422
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分子量
52kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KYAT1, or kynurenine alpha-ketoglutarate transaminase 1, is an enzyme involved in the kynurenine pathway, which is crucial for tryptophan metabolism and the production of bioactive metabolites influencing various physiological processes. Research indicates that KYAT1 plays a significant role in modulating neurotransmitter levels, particularly serotonin, and may be linked to neurodevelopmental disorders and psychiatric diseases, including depression and schizophrenia. Its activity also impacts the production of neuroprotective compounds, making it a potential target for therapeutic intervention. Investigating the recombinant protein of KYAT1 allows for a deeper understanding of its enzymatic properties, regulatory mechanisms, and potential interactions with other metabolites. Utilizing recombinant techniques enhances our ability to produce and study KYAT1 in vitro, facilitating the exploration of its structure-function relationships and its role in pathophysiological conditions. As ongoing studies aim to elucidate the enzyme's function in health and disease, KYAT1 remains an important focus within the fields of biochemistry, pharmacology, and neurobiology, with the hope of discovering novel therapeutic strategies that can ameliorate conditions associated with dysregulated tryptophan metabolism and related disorders.
