Analytical Data
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基因名
SULT1C2
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简介
The SULT1C2 protein utilizes PAPS to catalyze sulfate conjugation and has specific affinity for sulfonated p-nitrophenol. It selectively avoids sulfonated steroids, dopamine, acetaminophen or alpha-naphthol. SULT1C2 Protein, Human (His) is the recombinant human-derived SULT1C2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Sulfotransferase 1C2; ST1C2; Sulfotransferase 1C1; SULT1C#1; humSULTC2; SULT1C2; SULT1C1;
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00338
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表达区间
M1-L296
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氨基酸序列
MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL
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蛋白长度
Full Length
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分子量
38.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SULT1C2, a member of the sulfotransferase enzyme family, plays a crucial role in the metabolism of various endogenous and exogenous compounds by catalyzing the transfer of sulfate groups. Research on SULT1C2 is particularly significant due to its involvement in the biotransformation of drugs, hormones, and neurotransmitters, influencing their pharmacokinetics and pharmacodynamics. Its activity can modulate the bioavailability and toxicity of many substances, making it an essential target for understanding individual differences in drug response and the development of pharmacogenomic strategies. The study of SULT1C2 also extends to its role in steroid biosynthesis and metabolism, where it may impact reproductive health and developmental processes. Recent advances in recombinant DNA technology have facilitated the production of recombinant SULT1C2 proteins, enabling detailed biochemical and structural studies. These efforts aim to elucidate the enzyme's substrate specificity, catalytic mechanisms, and regulatory pathways, which can ultimately contribute to the development of therapeutic interventions and the assessment of drug interactions. Understanding the functional implications of SULT1C2 is pivotal not only for pharmacology but also for personalized medicine approaches, wherein individual variations in sulfation capacities can influence treatment efficacy and safety profiles.
