Analytical Data
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基因名
SMAD3
- Application
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别名
JV15-2SMAD family member 3 ;SMAD 3 ;Smad3 ;hSMAD3
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种属
Human
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表达系统
Baculovirus
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标签
N- His
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纯度
Greater than 85% as determined by SDS-PAGE.
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蛋白编号
P84022
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表达区间
1-425aa
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蛋白长度
Partial
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分子量
50.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMAD3 is a critical intracellular signaling protein that plays a key role in the transformating growth factor-beta (TGF-β) signaling pathway, which is involved in various cellular processes including cell growth, differentiation, and apoptosis. Dysregulation of SMAD3 has been linked to a number of diseases, including fibrosis, cancer, and cardiovascular diseases. As a member of the SMAD family, SMAD3 transmits signals from TGF-β ligands to the nucleus, where it regulates gene expression by forming complexes with other transcription factors. The study of recombinant SMAD3 protein is essential for understanding its biochemical properties, interaction with other proteins, and its functional role in TGF-β signaling. Researchers often use recombinant SMAD3 to investigate its structure-function relationships and to screen for potential therapeutic targets, particularly in contexts where TGF-β signaling is aberrant. Furthermore, characterization of SMAD3 at the molecular level can provide insights into its mechanisms of action and offer potential avenues for therapeutic intervention in diseases linked to TGF-β signaling dysregulation. Overall, the exploration of SMAD3 as a recombinant protein not only enhances our understanding of its biological functions but also holds promise for developing novel strategies for treating TGF-β-related diseases.
