Analytical Data
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Gene name
Serglycin/SRGN
- Application
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Alternative Names
PRG; PPG; PRG1; proteoglycan 1, secretory granule
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P10124
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Expression Region
Tyr28~Leu158
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Serglycin (SRGN) is a unique proteoglycan primarily found in hematopoietic cells and is characterized by its ability to bind various bioactive molecules, including cytokines, chemokines, and growth factors. Its primary role is believed to involve the regulation of immune responses and cell signaling, particularly in the context of inflammation and tumor progression. Research has shown that Serglycin is involved in the storage and release of these important regulatory molecules, which can influence the behavior of immune cells. There is growing interest in the therapeutic potential of Serglycin, particularly in cancer biology, where it may facilitate tumor growth and metastasis by modulating the tumor microenvironment. Recombinant Serglycin protein production has become a focal point in studies aimed at understanding its structural characteristics, functional roles, and interactions with other molecules. This research not only enhances our comprehension of immune modulation but also opens avenues for developing new strategies in cancer treatment and immunotherapy. By studying the recombinant protein's properties, researchers aim to elucidate the precise mechanisms through which Serglycin exerts its effects, thereby contributing to a more comprehensive understanding of its role in health and disease.
