Analytical Data
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Gene name
Lymphocyte antigen 6E/LY6E
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简介
Lymphocyte antigen 6E/LY6E protein is a GPI-anchored cell surface regulator that regulates T cell receptor signaling through interaction with CD3Z/CD247. It limits the entry of human coronaviruses, serves as the primary receptor for syncytin-A, and may modulate nicotinic acetylcholine receptor activity. Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) is the recombinant human-derived Lymphocyte antigen 6E/LY6E protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
- Application
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Alternative Names
LY6E; 9804; RIGE; SCA2; TSA1; Lymphocyte antigen 6E; Ly-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1
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Species
Human
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Source
E. coli
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Tag
N-His;N-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16553
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Expression Region
L21-S101
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Protein Length
Full Length of Mature Protein
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Molecular Weight
24.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Lymphocyte antigen 6E (LY6E) is a member of the LY6 gene family, which encodes glycosylphosphatidylinositol (GPI)-anchored proteins involved in immune responses. The study of LY6E has gained attention due to its role in modulating immune cell functions, particularly in lymphocytes. Research has shown that LY6E plays a critical role in influencing T cell activation, proliferation, and differentiation, thereby impacting overall immune responses. Furthermore, LY6E has been implicated in various diseases, including cancers and viral infections, where it may modulate the immune evasion mechanisms of pathogens or tumor cells. The recombinant LY6E protein serves as a valuable tool for elucidating the biological functions of this antigen and its potential therapeutic applications. By generating and characterizing the recombinant LY6E protein, researchers can explore its interactions with other immune receptors, assess its signal transduction pathways, and investigate its potential as a biomarker or therapeutic target. Overall, studying LY6E and its recombinant forms enhances our understanding of immune regulation and opens avenues for novel immunotherapeutic strategies.
