Analytical Data
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基因名
KIRREL2/NEPH3
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简介
KIRREL2/NEPH3 proteins may regulate basal insulin secretion and participate in self-association as homodimers. Functionally, it interacts with NPHS2/podocin, NPHS1 and FYN, contributing to key molecular interactions in cellular processes. KIRREL2/NEPH3 Protein, Human (HEK293, His) is the recombinant human-derived KIRREL2/NEPH3 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Kin of IRRE-like protein 2; Nephrin-like protein 3; NEPH3
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6UWL6-1
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表达区间
G21-R503
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蛋白长度
Partial
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分子量
52.3 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIRREL2 and NEPH3 are members of the nephrin-like cell adhesion molecule family, which play crucial roles in the development and maintenance of the renal glomerular filtration barrier and neuronal connections. Recent studies have highlighted the significance of these proteins in various physiological and pathological processes, including their involvement in kidney disease and neurodevelopmental disorders. KIRREL2 (Kin of IRRE Like 2) is known to interact with NEPH3 (Nephrin-like protein 3), facilitating their roles in promoting cell adhesion and signal transduction. This interaction suggests a unique mechanism by which cells communicate and organize in tissues such as the kidney and nervous system. The recombinant proteins KIRREL2 and NEPH3 have become valuable tools for researchers aiming to elucidate the molecular pathways underpinning their functions. By expressing these proteins in various systems, scientists can investigate their structural properties, binding affinities, and functional roles in cellular contexts. Understanding KIRREL2/NEPH3 interactions and their downstream effects may pave the way for novel therapeutic strategies targeting conditions like glomerulonephritis or neurological diseases. The study of these proteins is essential not only for comprehending normal cellular functions but also for devising interventions that could ameliorate the detrimental effects of their dysregulation.
