Analytical Data
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Gene name
KIRREL2/NEPH3
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简介
KIRREL2/NEPH3 proteins may regulate basal insulin secretion and participate in self-association as homodimers. Functionally, it interacts with NPHS2/podocin, NPHS1 and FYN, contributing to key molecular interactions in cellular processes. KIRREL2/NEPH3 Protein, Human (HEK293, His) is the recombinant human-derived KIRREL2/NEPH3 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Kin of IRRE-like protein 2; Nephrin-like protein 3; NEPH3
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UWL6-1
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Expression Region
G21-R503
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Protein Length
Partial
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Molecular Weight
52.3 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIRREL2 and NEPH3 are members of the nephrin-like cell adhesion molecule family, which play crucial roles in the development and maintenance of the renal glomerular filtration barrier and neuronal connections. Recent studies have highlighted the significance of these proteins in various physiological and pathological processes, including their involvement in kidney disease and neurodevelopmental disorders. KIRREL2 (Kin of IRRE Like 2) is known to interact with NEPH3 (Nephrin-like protein 3), facilitating their roles in promoting cell adhesion and signal transduction. This interaction suggests a unique mechanism by which cells communicate and organize in tissues such as the kidney and nervous system. The recombinant proteins KIRREL2 and NEPH3 have become valuable tools for researchers aiming to elucidate the molecular pathways underpinning their functions. By expressing these proteins in various systems, scientists can investigate their structural properties, binding affinities, and functional roles in cellular contexts. Understanding KIRREL2/NEPH3 interactions and their downstream effects may pave the way for novel therapeutic strategies targeting conditions like glomerulonephritis or neurological diseases. The study of these proteins is essential not only for comprehending normal cellular functions but also for devising interventions that could ameliorate the detrimental effects of their dysregulation.
