Analytical Data
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基因名
CERS6
- Application
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别名
LASS6
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种属
Human
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表达系统
HEK293
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标签
Strep;His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZMG9-1
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表达区间
M1-D384end
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蛋白长度
Full Length of Isoform-1
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CERS6 (Ceramide Synthase 6) is an essential enzyme involved in the biosynthesis of ceramides, which are crucial lipids playing vital roles in cellular signaling, membrane structure, and metabolic regulation. The study of CERS6 and its recombinant protein is significant due to its implications in various physiological and pathological processes, including skin barrier function, inflammation, and neurodegenerative diseases. Dysregulation of ceramide levels has been linked to conditions such as diabetes, obesity, and certain cancers, highlighting the importance of understanding CERS6's function and regulation. Researchers are increasingly focusing on the recombinant expression of CERS6 to facilitate the study of its enzymatic activity, substrate specificity, and interactions with other cellular proteins. The development of recombinant CERS6 protein offers potential insights into its structural and functional properties, enabling the exploration of therapeutic targets for diseases associated with altered ceramide metabolism. Furthermore, the characterization of CERS6 may provide a foundation for developing novel lipid-based therapies and enhance our understanding of lipid biology in health and disease. As such, CERS6 stands at the intersection of biochemistry, molecular biology, and medicine, representing an exciting frontier for future research efforts aimed at unraveling the complexities of lipid-mediated signaling pathways.












