Analytical Data
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Gene name
CERS6
- Application
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Alternative Names
LASS6
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Species
Human
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Source
HEK293
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Tag
Strep;His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZMG9-1
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Expression Region
M1-D384end
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CERS6 (Ceramide Synthase 6) is an essential enzyme involved in the biosynthesis of ceramides, which are crucial lipids playing vital roles in cellular signaling, membrane structure, and metabolic regulation. The study of CERS6 and its recombinant protein is significant due to its implications in various physiological and pathological processes, including skin barrier function, inflammation, and neurodegenerative diseases. Dysregulation of ceramide levels has been linked to conditions such as diabetes, obesity, and certain cancers, highlighting the importance of understanding CERS6's function and regulation. Researchers are increasingly focusing on the recombinant expression of CERS6 to facilitate the study of its enzymatic activity, substrate specificity, and interactions with other cellular proteins. The development of recombinant CERS6 protein offers potential insights into its structural and functional properties, enabling the exploration of therapeutic targets for diseases associated with altered ceramide metabolism. Furthermore, the characterization of CERS6 may provide a foundation for developing novel lipid-based therapies and enhance our understanding of lipid biology in health and disease. As such, CERS6 stands at the intersection of biochemistry, molecular biology, and medicine, representing an exciting frontier for future research efforts aimed at unraveling the complexities of lipid-mediated signaling pathways.
