Analytical Data
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Gene name
NLRP4
- Application
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Alternative Names
NALP4; PAN2; PYPAF4; RNH2
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Species
Human
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Source
Baculovirus
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Tag
Strep;His;MBP
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MN2-1
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Expression Region
M1-I994
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NLRP4, a member of the NOD-like receptor (NLR) family, plays a crucial role in the innate immune response, particularly in the recognition of pathogens and the regulation of inflammation. As a cytosolic sensor, NLRP4 is involved in forming inflammasomes, which are multiprotein complexes that activate caspases and lead to the release of pro-inflammatory cytokines. Research has indicated that NLRP4 can detect a variety of microbial products, leading to its activation and subsequent inflammatory responses. aberrations in NLRP4 function have been linked to several diseases, including autoimmune disorders and infections. Given its importance in immune regulation, the study of NLRP4 recombinant proteins is essential for understanding its structure-function relationships and mechanisms of action. Recombinant proteins enable researchers to dissect the molecular pathways involved, assess the role of NLRP4 in immune signaling, and develop potential therapeutic strategies targeting NLRP4-related pathologies. Moreover, the production and characterization of recombinant NLRP4 offer valuable insights for drug design and the development of vaccines aimed at modulating immune responses. Overall, the investigation of NLRP4 recombinant proteins is a promising area of research with significant implications for improving our understanding of immune regulation and developing innovative treatments for inflammatory diseases.
