Recombinant Human SLC34A3 Protein (HEK293)，Flag & Strep

SLC34A3, a member of the SLC34 family of sodium-dependent phosphate transporters, plays a crucial role in maintaining phosphate homeostasis in the body. This protein is primarily expressed in the kidneys and intestines, where it facilitates the reabsorption of phosphate from the renal tubules and absorption from the gastrointestinal tract. Mutations in the SLC34A3 gene can lead to familial hypophosphatemic rickets, a disorder characterized by impaired phosphate reabsorption resulting in phosphate wasting, bone pain, and growth abnormalities in children. Given the significance of phosphate in various biological processes, including energy metabolism, skeletal health, and cellular signaling, understanding the functional properties of SLC34A3 is essential. Recombinant SLC34A3 protein studies provide valuable insights into its transport mechanism, substrate specificity, and regulatory pathways. Furthermore, by analyzing its interactions with other cellular proteins and assessing its pharmacological properties, researchers aim to uncover potential therapeutic targets for conditions associated with phosphate dysregulation. The recombinant expression and purification of SLC34A3 not only facilitate structural and functional analyses but also contribute to the development of novel strategies to ameliorate diseases resulting from SLC34A3 dysfunction. This research area is increasingly important as it intersects with broader implications related to bone health, mineral metabolism, and the development of treatment modalities for metabolic disorders.