Analytical Data
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Gene name
SLC12A7
- Application
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Alternative Names
KCC4
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Species
Human
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Source
HEK293
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Tag
His;MBP;Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y666-1
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Expression Region
P2-S1083
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC12A7, a member of the SLC12 family of solute carriers, encodes a sodium-potassium-chloride co-transporter primarily expressed in various tissues, including the brain and kidney. This protein plays a crucial role in maintaining cellular ion balance and homeostasis, influencing processes like cell volume regulation and neurotransmitter release. Abnormal functioning of SLC12A7 has been implicated in a range of physiological disorders, including hypertension and neurological diseases. Recent studies have highlighted its potential as a therapeutic target, prompting researchers to investigate the structure and function of SLC12A7 through recombinant protein production. By utilizing techniques such as gene cloning and protein expression systems, scientists aim to generate and purify functional SLC12A7 protein for detailed biochemical characterization. This research not only enhances our understanding of the physiological roles of SLC12A7 but also paves the way for the development of novel interventions that could modulate its activity in disease contexts. The successful production of recombinant SLC12A7 would facilitate high-throughput screening for potential modulators, thus contributing to drug discovery efforts targeting ion transport mechanisms. Overall, the study of SLC12A7 at the molecular level is pivotal in elucidating its contributions to cellular physiology and its potential role in disease management.
