Analytical Data
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基因名
CANT1
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简介
CANT1 is a calcium-dependent nucleotidase that shows a clear preference for UDP, and the order of its enzymatic activity is UDP > GDP > UTP > GTP. It is worth noting that it has little activity on ADP and even less activity on ATP, but it does not hydrolyze AMP and GMP. CANT1 Protein, Human (HEK293, Fc) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
Soluble calcium-activated nucleotidase 1; SCAN-1; CANT1; SHAPY
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种属
Human
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WVQ1-1
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表达区间
G80-I401
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蛋白长度
Partial
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CANT1 (calcium-activated nucleotidase 1) is an enzyme that plays a pivotal role in nucleotide metabolism, particularly in the hydrolysis of ATP and other nucleotides. Its importance has been underscored by its association with various physiological processes, including cellular signaling and energy metabolism. Recent research has highlighted the relevance of CANT1 in several pathological conditions, such as neurological disorders, where its dysfunction may contribute to disease progression. Moreover, mutations in the CANT1 gene have been linked to a rare autosomal recessive disorder known as 'CANT1 deficiency,' which is characterized by skeletal abnormalities and developmental delays. Given its critical functions and the implications of CANT1's dysfunction, the study of CANT1 recombinant protein has gained traction. By expressing and purifying CANT1, scientists aim to elucidate its structure-function relationships and regulatory mechanisms, paving the way for potential therapeutic interventions. This recombinant protein serves as a valuable tool for biochemical assays, helping researchers to explore the enzyme's activity, interaction with substrates, and influence on cellular pathways. Ultimately, in-depth understanding of CANT1's role may lead to novel approaches in treating related diseases and enhancing our knowledge of nucleotide signaling pathways in health and disease.
