Analytical Data
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Gene name
CANT1
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简介
CANT1 is a calcium-dependent nucleotidase that shows a clear preference for UDP, and the order of its enzymatic activity is UDP > GDP > UTP > GTP. It is worth noting that it has little activity on ADP and even less activity on ATP, but it does not hydrolyze AMP and GMP. CANT1 Protein, Human (HEK293, Fc) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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Alternative Names
Soluble calcium-activated nucleotidase 1; SCAN-1; CANT1; SHAPY
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Species
Human
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WVQ1-1
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Expression Region
G80-I401
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Protein Length
Partial
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Molecular Weight
65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CANT1 (calcium-activated nucleotidase 1) is an enzyme that plays a pivotal role in nucleotide metabolism, particularly in the hydrolysis of ATP and other nucleotides. Its importance has been underscored by its association with various physiological processes, including cellular signaling and energy metabolism. Recent research has highlighted the relevance of CANT1 in several pathological conditions, such as neurological disorders, where its dysfunction may contribute to disease progression. Moreover, mutations in the CANT1 gene have been linked to a rare autosomal recessive disorder known as 'CANT1 deficiency,' which is characterized by skeletal abnormalities and developmental delays. Given its critical functions and the implications of CANT1's dysfunction, the study of CANT1 recombinant protein has gained traction. By expressing and purifying CANT1, scientists aim to elucidate its structure-function relationships and regulatory mechanisms, paving the way for potential therapeutic interventions. This recombinant protein serves as a valuable tool for biochemical assays, helping researchers to explore the enzyme's activity, interaction with substrates, and influence on cellular pathways. Ultimately, in-depth understanding of CANT1's role may lead to novel approaches in treating related diseases and enhancing our knowledge of nucleotide signaling pathways in health and disease.
