Analytical Data
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Gene name
ACVR2A/Activin RIIA
- Application
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Alternative Names
ACVR2-A; ACTRII; ACTR-II; ACVR2
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Species
Bovine
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q28043
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Expression Region
Ala20~Pro135
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Protein Length
Partial
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Molecular Weight
17kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR2A, also known as Activin Receptor Type IIA, is a crucial component of the TGF-β superfamily of receptors, playing a significant role in various biological processes, including embryonic development, cell proliferation, and differentiation. The receptor is primarily involved in mediating the effects of activin and myostatin, making it essential for muscle growth regulation and various cellular functions. Abnormalities in ACVR2A signaling have been linked to several pathological conditions, such as cancer, muscle wasting, and fibrotic diseases. Consequently, understanding the structure and function of ACVR2A is vital for developing targeted therapies. Recombinant ACVR2A proteins facilitate the exploration of its biological roles and interactions with ligands, providing insights into its mechanisms in cellular signaling pathways. These proteins are valuable tools in both basic and translational research, helping to elucidate the receptor's role in disease and identify potential therapeutic targets. By employing recombinant techniques, researchers can produce active, high-purity ACVR2A proteins, making them essential for studying receptor dynamics, ligand binding affinities, and downstream signaling events. The development of ACVR2A recombinant proteins thus holds promise for advancing our understanding of its biological functions and therapeutic implications, particularly in muscle-related disorders and cancers, where modulating its activity might offer novel intervention strategies.
