Analytical Data
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基因名
KCNQ4
- Application
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种属
Human
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表达系统
HEK293
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56696-1
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表达区间
M1-D695
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蛋白长度
Full Length of Isoform-1
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNQ4, a member of the KCNQ potassium channel family, plays a crucial role in auditory function and is predominantly expressed in the inner ear's cochlear hair cells. Mutations in the KCNQ4 gene have been linked to autosomal dominant variants of hearing loss, highlighting its importance in auditory signal transduction. Research on KCNQ4 recombinant proteins aims to elucidate their biophysical properties, including ion conductance, activation kinetics, and pharmacological profiles, which are essential for understanding channel function and regulation. The characterization of KCNQ4 is critical not only for fundamental science but also for potential therapeutic strategies for hearing impairments caused by KCNQ4 mutations. Techniques such as heterologous expression in systems like Xenopus oocytes or mammalian cells have been employed to analyze KCNQ4 channel function. By studying the underlying mechanisms of KCNQ4 activity, researchers hope to develop targeted treatments for genetic hearing loss and contribute to the broader understanding of ion channel physiology.
