Analytical Data
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Gene name
SLC16A3-BSG2
- Application
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Alternative Names
MCT3; MCT4
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Species
Human
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Source
Baculovirus
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Tag
C-StrepⅡ;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15427 (M1-V465) & P35613
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Expression Region
O15427 (M1-V465) & P35613 (G140-S385)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC16A3-BSG2 recombinant protein is a subject of interest in biomedical research due to its potential implications in cellular transport mechanisms and metabolic regulation. The SLC16A3 gene, also known as the monocarboxylic acid transporter 4 (MCT4), is involved in the transport of lactate and other monocarboxylates across cellular membranes, playing a crucial role in maintaining cellular homeostasis, especially in excitable tissues such as muscles and neurons. BSG2, on the other hand, codes for basigin, a transmembrane protein that serves as a chaperone for MCT proteins, aiding in their stability and functionality. The interaction between SLC16A3 and BSG2 is vital for proper cellular lactate efflux, which is particularly critical in anaerobic conditions where lactate accumulation can lead to cellular acidosis. Dysregulation of this pathway has been linked to various pathological conditions, including cancer, where altered lactate metabolism contributes to the Warburg effect, thereby promoting tumor growth and survival. Consequently, the study of SLC16A3-BSG2 recombinant protein can provide insights into metabolic diseases and cancer biology, offering pathways for potential therapeutic interventions. Understanding their molecular mechanisms and interactions could lead to the development of novel strategies to target metabolic dysregulation in various diseases, marking a significant step forward in the field of metabolic and cancer research.
