Analytical Data
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基因名
VEGF-A
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简介
The VEGF-A protein is a multifunctional growth factor that is essential for promoting angiogenesis, vasculogenesis, and endothelial cell growth. Its multiple effects include inducing endothelial cell proliferation, promoting migration, inhibiting apoptosis, and increasing vascular permeability. VEGF-A Protein, Rabbit (His-SUMO) is the recombinant Rabbit-derived VEGF-A protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
- Application
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别名
VEGFA; VPF; VEGF; MVCD1; vascular endothelial growth factor A; vascular permeability factor
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种属
Rabbit
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表达系统
E. coli
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标签
N-SUMO;N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_002714743.1
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表达区间
Y51-R511
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氨基酸序列
YLWLLHAPLLHVSLDSLVAAFSVVFEVLPSSLDIPGSKKEEQASTQLGGVEEEHEASGVVTRQLAFVVDAITNPTLEKETKTITRIHKAPKFPSHFGFWKRAEEERGGKSSGEKSRKTDGVGERAQAGEQREGPGQRAAALTDRQTDTAPSPSAHLLPGRRPTVDAAASGGQQPEPAPEGGVEGVGARGIALKLFVQLLGCSRSGGVVVRAGGAEPSGAARSVSSGREEPPPPPPEEEGEEEGEKEEERGPRWRLGAGEPGSWTGEAAVCADSAPAARAPQALARASAPGARGARGGAEESGPSRSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEEGDNKPHEVVKFMEVYRRSYCQPIETLVDIFQEYPDEIEYIFKPSCVPLVRCGGCCNDESLECVPTEEFNVTMQIMRIKPHQGQHIGEMSFLQHNKCECRCDKPRR
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蛋白长度
Partial
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分子量
55-66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Vascular Endothelial Growth Factor A (VEGF-A) is a pivotal signaling protein that plays a critical role in angiogenesis, vasculogenesis, and endothelial cell function. Its primary function is to stimulate the proliferation and migration of endothelial cells, thereby facilitating the formation of new blood vessels. Research on VEGF-A has garnered significant attention due to its involvement in various physiological and pathological processes, including development, wound healing, and cancer progression. Elevated levels of VEGF-A are often associated with tumor growth and metastasis, making it a key target in cancer therapy. Furthermore, VEGF-A is implicated in ocular diseases, such as age-related macular degeneration and diabetic retinopathy, where aberrant angiogenesis leads to vision loss. Studies have shown that recombinant VEGF-A proteins can be utilized to investigate its mechanisms of action and the effects of its inhibition or overexpression in cellular models. Additionally, therapeutic strategies involving VEGF-A neutralizing antibodies or small molecule inhibitors are under exploration to manage diseases characterized by excessive angiogenesis. Given these multifaceted roles, the characterization of VEGF-A recombinant proteins is essential for developing targeted therapies and enhancing our understanding of angiogenic processes in health and disease, thus highlighting the significance of ongoing research in this domain.
