Analytical Data
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基因名
HNF1A
- Application
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别名
TCF1; HNF1; LFB1; LF-B1; MODY3; Transcription Factor 1,Hepatic; Hepatic Nuclear Factor; Albumin Proximal Factor; Liver-specific transcription factor LF-B1
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种属
Mouse
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22361
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表达区间
Asp56~Arg321
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分子量
60kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNF1A (Hepatocyte Nuclear Factor 1 Alpha) is a transcription factor that plays a crucial role in the regulation of genes involved in glucose metabolism, liver function, and pancreatic development. Mutations in the HNF1A gene are associated with a form of maturity-onset diabetes of the young (MODY3), characterized by early-onset diabetes and various renal and metabolic disorders. The study of HNF1A recombinant proteins is vital for understanding the molecular mechanisms underlying these conditions and for developing targeted therapies. Recombinant HNF1A proteins can be produced in various expression systems, such as bacteria or yeast, allowing for high yield and functional studies. Research on these proteins helps elucidate their structure-function relationships, post-translational modifications, and interactions with other regulatory factors. Furthermore, investigating HNF1A's role in gene expression and its pathway interactions could lead to insights into therapeutic interventions for MODY3 and related metabolic syndromes. Overall, the exploration of HNF1A recombinant proteins is a promising area of research that bridges genetic, biochemical, and therapeutic domains, contributing to the understanding of diabetes and metabolic diseases at a fundamental level.
