Analytical Data
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基因名
Activin RIB/ALK-4
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简介
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B[1][2][3]. Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 100 amino acids (R27-E126).
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When Recombinant Rhesus Macaque ALK-4/Activin RIB Protein is immobilized at 2µg/mL (100 µL/well) can bind Recombinant Human TDGF1. The ED50 for this effect is 18.31 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Rhesus Macaque ALK-4/Activin RIB Protein is immobilized at 2 µg/mL (100 µL/well) can bind Recombinant Human TDGF1. The ED50 for this effect is 18.31 ng/mL.
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别名
Activin Receptor IB; ALK-4; Activin RIB; ACVR1B
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种属
Rhesus Macaque
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
I2CYX8
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表达区间
R27-E126
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蛋白长度
Partial
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分子量
43-45 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Activin receptor type IIB (Activin RIB or ALK-4) is a pivotal member of the transforming growth factor-beta (TGF-β) superfamily, which is critically involved in various cellular processes, including cell differentiation, proliferation, and apoptosis. This receptor primarily binds to activin, a key regulator of numerous biological functions such as embryonic development, tissue homeostasis, and later stages of inflammation and immune responses. Research has revealed that dysregulation of the activin signaling pathway, mediated through Activin RIB/ALK-4, is associated with various pathologies, including fibrosis, cancer, and autoimmune diseases. The development of recombinant Activin RIB/ALK-4 proteins has opened new avenues for therapeutic interventions by providing tools for studying receptor interactions and downstream signaling pathways in cellular contexts. Furthermore, these recombinant proteins can serve as potential agents for modulating activin signaling, enabling the exploration of their roles in disease pathogenesis and treatment. The ongoing research into Activin RIB/ALK-4 recombinants aims to elucidate their functional characteristics and therapeutic potential, paving the way for innovative approaches in regenerative medicine and immunotherapy.
