Analytical Data
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基因名
PPP2R5A
- Application
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种属
Human
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表达系统
E. coli
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标签
Strep;His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15172-1
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表达区间
S2-E486
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蛋白长度
Full Length of Isoform-1 Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP2R5A, also known as protein phosphatase 2 regulatory subunit B alpha, plays a crucial role in the regulation of protein phosphatase 2A (PP2A), a vital serine/threonine phosphatase involved in various cellular processes such as cell growth, differentiation, and apoptosis. The PPP2R5A subunit is responsible for directing PP2A to specific substrates and cellular compartments, thereby modulating its activity and specificity. Studies have indicated that dysregulation of PPP2R5A and PP2A can lead to various pathological conditions, including cancer, neurodegenerative disorders, and cardiovascular diseases. Researchers are increasingly interested in recombinant forms of PPP2R5A to better understand its structural and functional properties, interaction with other proteins, and its role in signaling pathways. The production of PPP2R5A as a recombinant protein allows for detailed biochemical and biophysical characterization, enabling scientists to investigate its mechanisms of action and its potential as a therapeutic target. Understanding the function and regulation of PPP2R5A could provide insights into developing novel strategies for treating diseases associated with PP2A dysfunction, emphasizing the importance of this protein in both basic research and clinical applications.
