Analytical Data
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Gene name
PPP2R5A
- Application
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Species
Human
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Source
E. coli
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Tag
Strep;His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15172-1
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Expression Region
S2-E486
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Protein Length
Full Length of Isoform-1 Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP2R5A, also known as protein phosphatase 2 regulatory subunit B alpha, plays a crucial role in the regulation of protein phosphatase 2A (PP2A), a vital serine/threonine phosphatase involved in various cellular processes such as cell growth, differentiation, and apoptosis. The PPP2R5A subunit is responsible for directing PP2A to specific substrates and cellular compartments, thereby modulating its activity and specificity. Studies have indicated that dysregulation of PPP2R5A and PP2A can lead to various pathological conditions, including cancer, neurodegenerative disorders, and cardiovascular diseases. Researchers are increasingly interested in recombinant forms of PPP2R5A to better understand its structural and functional properties, interaction with other proteins, and its role in signaling pathways. The production of PPP2R5A as a recombinant protein allows for detailed biochemical and biophysical characterization, enabling scientists to investigate its mechanisms of action and its potential as a therapeutic target. Understanding the function and regulation of PPP2R5A could provide insights into developing novel strategies for treating diseases associated with PP2A dysfunction, emphasizing the importance of this protein in both basic research and clinical applications.
