Analytical Data
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基因名
NONO
- Application
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别名
P54; NMT55; NRB54; P54NRB; Nuclear RNA-Binding Protein 54-kD; 54 kDa nuclear RNA- and DNA-binding protein; DNA-binding p52/p100 complex, 52 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15233
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表达区间
Lys18~Asp228
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分子量
54kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NONO, a member of the non-POU domain containing octamer-binding protein family, plays a crucial role in various cellular processes, including RNA metabolism, transcription regulation, and stress response. Its involvement in the regulation of gene expression and splicing mechanisms has garnered significant attention in the field of molecular biology. Recent studies have highlighted NONO's dual functions in both nuclear processes and the cytoplasmic response to stress, indicating its importance in maintaining cellular homeostasis. Additionally, NONO has been implicated in several diseases, including cancer and neurodegenerative disorders, where its dysregulation can contribute to pathogenesis. Research focusing on the structure and dynamics of NONO, particularly its protein-protein interactions and post-translational modifications, is vital for understanding its diverse functions. Emerging evidence suggests that NONO may serve as a potential therapeutic target, making it imperative to deepen our understanding of its biochemical properties and the impact of its restructured forms in various biological contexts.
