Analytical Data
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Gene name
VEGF120
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简介
VEGF-A Protein is a key member of the VEGF family of cytokines.VEGF-A participates in angiogenesis, vasculogenesis, and endothelial cell growth, inducing endothelial cell proliferation, promoting cell migration, inhibiting cell apoptosis, and inducing vascular permeability.VEGF-A stimulates endothelial cell mitogenesis and cell migration.VEGF120 Protein, Mouse is the recombinant mouse-derived VEGF120 protein, expressed by E.coli , with tag free.
- Application
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Alternative Names
VEGF-AA; Vascular endothelial growth factor A; VPF; VEGFA
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q00731-3
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Expression Region
A27-R146
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Protein Length
Partial
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Molecular Weight
17 kDa under reduced (R) conditions, 36 kDa under non reducing (N) conditions, based on SDS-PAGE.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Vascular Endothelial Growth Factor 120 (VEGF120) is a potent angiogenic factor that plays a critical role in the regulation of blood vessel formation. Understanding its biological functions and mechanisms of action has significant implications in both physiological and pathological conditions, such as cancer, ischemia, and inflammatory diseases. While several isoforms of VEGF exist, VEGF120 is notable because it lacks certain heparin-binding domains that are present in other isoforms, leading to a unique profile in promoting endothelial cell proliferation and migration. Recent studies have focused on the recombinant production of VEGF120 to explore its functional properties further and its potential therapeutic applications. The use of recombinant technology allows for the generation of high-purity VEGF120, facilitating detailed investigations into its signaling pathways and interactions with other growth factors. Additionally, research into VEGF120 may contribute to the development of targeted therapies aimed at modulating angiogenesis and improving treatment outcomes in various disorders characterized by abnormal vascular growth. By elucidating the roles of VEGF120 in both health and disease, researchers aim to harness its properties for innovative therapeutic interventions, addressing unmet medical needs in areas such as tumor vascularization and wound healing. As a result, VEGF120 has emerged as a focal point in angiogenesis research, offering valuable insights into the complexities of vascular biology and its implications for clinical applications.
