Analytical Data
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基因名
ACVR1
- Application
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别名
ACVR1A; ALK2; ACVRLK2; TSRI; FOP; SKR1; ACTRI; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q04771
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表达区间
Ile208~Lys340
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蛋白长度
Partial
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分子量
15kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1, also known as Activin A receptor type 1, is a member of the transforming growth factor-beta (TGF-β) superfamily, which plays a critical role in various cellular processes, including differentiation, proliferation, and apoptosis. Mutations in the ACVR1 gene have been implicated in several disorders, most notably Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic condition characterized by abnormal bone formation in soft tissues. The study of ACVR1 recombinant protein is crucial for understanding the mechanisms underlying these pathological processes and for developing potential therapeutic interventions. By producing and characterizing ACVR1 recombinant proteins, researchers can explore the receptor's signaling pathways and its interactions with ligands, thereby elucidating how mutations alter its function and contribute to disease. Moreover, recombinant ACVR1 proteins serve as valuable tools in drug discovery and biomarker development, providing insights into targeted therapies for FOP and other related disorders. Understanding the structural and functional aspects of ACVR1 will pave the way for innovative treatments that could improve patient outcomes in conditions associated with aberrant bone growth and tissue remodeling.
