Analytical Data
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基因名
CCNB1
- Application
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别名
CCNB
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14635-1
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表达区间
N165-V433, C167S, C238S, C350S
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCNB1, or Cyclin B1, is a crucial regulatory protein involved in the cell cycle, specifically in the transition between the G2 phase and mitosis. It partners with CDC2 (Cyclin-dependent kinase 1) to form the maturation-promoting factor (MPF), which initiates the processes necessary for cell division. Dysregulation of CCNB1 has been implicated in various cancers, making it a significant focus of oncological research. Understanding CCNB1's structure and function can provide insights into the mechanisms of cell cycle regulation and tumorigenesis. Researchers have utilized recombinant protein technology to produce CCNB1, allowing for detailed studies on its interaction with other cell cycle proteins, the effects of phosphorylation on its activity, and its role in checkpoint regulation. The ability to generate large quantities of purified CCNB1 is pivotal for drug development efforts aimed at targeting its pathways in cancer therapy. Moreover, studies have shown that CCNB1 levels are often upregulated in malignant tissues, correlating with poor prognosis in several cancers. Thus, the investigation of CCNB1 not only enhances our understanding of cell cycle control but also opens avenues for potential therapeutic interventions in cancer treatment.
