Analytical Data
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基因名
BMPRIB/ALK-6
- Application
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别名
Bone morphogenetic protein receptor type-1B; BMPR-1B; CDw293
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00238
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表达区间
K14-R126
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蛋白长度
Extracellular Domain
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分子量
110 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
Bone morphogenetic protein receptor type IB (BMPRIB), also known as activin-like kinase 6 (ALK-6), is a member of the transforming growth factor-beta (TGF-β) superfamily, playing a crucial role in various biological processes such as embryonic development, tissue homeostasis, and cellular differentiation. Studies on BMPRIB/ALK-6 have gained significant attention due to its implications in bone formation, cardiovascular development, and the regulation of cellular signaling pathways, particularly the SMAD-dependent and non-SMAD pathways. Dysregulation of BMPRIB/ALK-6 signaling has been linked to several diseases, including pulmonary arterial hypertension and various forms of cancer, making it a potential therapeutic target. Recent research efforts focus on elucidating the structural and functional aspects of this receptor, its binding affinities with ligands, and how it interacts with other cellular components. Understanding the mechanisms by which BMPRIB/ALK-6 regulates cellular processes may open new avenues for innovative treatment strategies in regenerative medicine and oncology, emphasizing the need for continued investigation into its biological significance and potential clinical applications.
