Analytical Data
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基因名
CART
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简介
CART Protein, a satiety factor, intricately regulates feeding in connection with leptin and neuropeptide Y. It effectively suppresses regular and starvation-triggered feeding, robustly inhibiting neuropeptide Y-initiated feeding within the hypothalamus. Additionally, CART protein plays a pivotal role in fostering neuronal development and survival in vitro, extending beyond its appetite regulation function. CART Protein, Human (HEK293, Fc) is the recombinant human-derived CART protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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别名
Cocaine- and amphetamine-regulated transcript protein; CART; CARTPT
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种属
Human
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表达系统
HEK293
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标签
C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16568
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表达区间
Q28-L116
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蛋白长度
Full Length of Mature Protein
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CART (Cocaine- and Amphetamine-Regulated Transcript) is a neuropeptide that plays a significant role in the regulation of various physiological processes, including appetite control, stress response, and reward pathways. First discovered in the mid-1990s, CART has gained attention due to its involvement in addictive behaviors and potential implications in obesity and eating disorders. Research has revealed that CART expression can be modulated by psychoactive substances, suggesting a link between this peptide and the mechanisms of addiction. Furthermore, studies have shown that CART interacts with several neurotransmitter systems, including dopamine and serotonin, indicating its crucial role in the brain's reward circuitry. Given its diverse biological functions, CART has emerged as a promising target for therapeutic interventions in metabolic disorders and substance abuse. Recent advances in recombinant protein techniques have facilitated the production and characterization of CART, allowing for more in-depth studies into its structure-function relationship and mechanisms of action. Understanding CART's role in the central nervous system may provide insights that inform the development of novel treatment strategies for a range of conditions, highlighting the importance of continued research in this field.
