Analytical Data
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Gene name
p73 alpha
- Application
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Alternative Names
P73; p73 alpha Protein; TP73
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15350-1
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Expression Region
M1-H636
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
p73 alpha is a member of the p53 family of transcription factors, which plays a crucial role in the regulation of the cell cycle, apoptosis, and DNA repair. Unlike its well-characterized counterpart, p53, p73 has been shown to have both pro-apoptotic and anti-apoptotic functions, depending on the cellular context and the presence of specific isoforms. The study of p73 alpha, particularly its recombinantly expressed protein, has garnered considerable interest due to its potential implications in cancer research. Many tumors exhibit alterations in p53 signaling, leading to the activation of alternative pathways. Research on p73 alpha aims to investigate its role in tumorigenesis, as well as its interactions with other cellular proteins, which could shed light on novel therapeutic strategies. Recent studies have highlighted the significance of p73 alpha in response to various stress signals, suggesting that it may possess unique regulatory mechanisms that could be exploited in cancer treatment. Furthermore, understanding the structure and function of p73 alpha at the molecular level can reveal insights into its activation and transcriptional regulation, thus paving the way for its application in targeted therapies and drug design. As researchers continue to explore the potential of p73 alpha, its study not only contributes to the fundamental understanding of tumor biology but also holds promise for the development of innovative approaches to combat cancers that are resistant to conventional treatments.
