Analytical Data
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基因名
IL-31R alpha
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简介
The IL-31R alpha protein is critical to the immune response and forms the interleukin 31 receptor with OSMR. It activates STAT3, and to a lesser extent STAT1 and STAT5, is associated with skin immunity and mediates IL31-induced itch, possibly involving the cation channels TRPA1 and TRPV1. IL-31R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31R alpha protein, expressed by HEK293 , with a C-His labeled tag.
- Application
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别名
IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr; GLM-RMGC125346; PRO21384
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8K5B1-1
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表达区间
V19-T499
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蛋白长度
Extracellular Domain
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分子量
80-115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-31R alpha, a crucial receptor component for interleukin-31 (IL-31), is integral to understanding various inflammatory and allergic conditions, particularly in atopic dermatitis and asthma. IL-31, a cytokine produced primarily by T-helper 2 (Th2) cells, is implicated in mediating itch and promoting inflammation in these diseases. The interaction between IL-31 and its receptor, IL-31R alpha, initiates intracellular signaling pathways that lead to the activation of multiple pro-inflammatory factors. Recent studies have highlighted the overexpression of IL-31 and its receptor in skin lesions and in the serum of patients suffering from atopic dermatitis, establishing their role in the pathophysiology of the disease. Given the association of IL-31 with chronic pruritus and skin inflammation, the development of IL-31R alpha recombinant proteins holds therapeutic potential. These proteins can be utilized both as research tools to elucidate the signaling mechanisms involved and as potential biotherapeutics for blocking the IL-31/IL-31R alpha pathway, aiming to alleviate symptoms and improve patient outcomes in inflammatory skin disorders. With the increasing prevalence of allergic diseases, understanding the role of IL-31R alpha offers promising avenues for targeted therapies that could significantly impact the quality of life of affected individuals.
