Analytical Data
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Gene name
UPK2
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简介
UPK2 is a key component of the asymmetric unit membrane (AUM), a specialized biofilm made by terminally differentiated urothelial cells. Its presence suggests a potentially critical role in the complex regulation of AUM assembly. UPK2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived UPK2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag.
- Application
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Alternative Names
Uroplakin-2; Uroplakin II; UPII
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Species
Human
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Source
E. coli Cell-free
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Tag
N-6*His;N-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00526
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Expression Region
E85-K184
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of UPK2 (Uroplakin 2) recombinant protein is rooted in its critical role in the formation and function of the urothelial barrier, which lines the urinary tract. UPK2 is a member of the uroplakin family, proteins that are essential for the structural integrity of the bladder epithelium, providing protection against urine's toxic components and pathogens. Alterations in UPK2 expression have been linked to various urological diseases, including bladder cancer and urinary tract infections. The recombinant form of UPK2 enables researchers to explore its biochemical properties, interactions, and potential as a therapeutic target. By producing UPK2 in a controlled laboratory setting, scientists can study its role in urinary tract physiology and pathology, assess its potential as a biomarker for diseases, and investigate vaccine development for uropathogenic bacteria by using UPK2 as a platform for immunogenic studies. Understanding UPK2's molecular mechanisms could lead to novel therapeutic interventions for urological disorders and enhance our knowledge of bladder biology.
